Prince (18 points), Zach Randolph (16, eight rebounds), Mike Conley (16, eight assists) and Austin Daye (16 points) combined to go 28-of-45 from the field as Memphis reeled off its ninth straight win against the Timberwolves.
Marc Gasol tallied nine points, nine boards and eight assists for the Grizzlies.
The spiraling T-Wolves, meanwhile, played without J.J. Barea (foot), Andrei Kirilenko (strained quadriceps) and Kevin Love (hand surgery) in dropping their 15th in 17 games.
Luke Ridnour and Ricky Rubio each provided 17 points for Minnesota.
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