Kirkwood led 37-25 at the half.
NIACC was led by Orrington Hamilton with 22 points. Hollis Hardwick was next in line with 16 points.
Also for NIACC, Jaycob Payne scored eight points and grabbed 13 rebounds. Mac Skogen scored five points and collected seven rebounds.
NIACC returns to action Saturday at home against Iowa Central. Game time is set for 3 p.m. in the NIACC gym.